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KMID : 0603820070130020157
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Journal of Experimental & Biomedical Science
2007 Volume.13 No. 2 p.157 ~ p.160
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Up-regulation of Early Growth Response-1 Expression by Endoplasmic Reticulum Stress
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Han Song-Yi
Kwon Ki-Sang
Yun Eun-Young
Kwon O-Yu
Goo Tae-Won
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Abstract
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Endoplasmic reticulum (ER) plays formation of disulfide bonds and proper folding of secretory proteins. Cellular responses to ER stress enhances the stress-activated kinase pathway and the induces a lot of immediate-early genes. Among of them, the early growth response-1 (Egr-1), a transcription factor, which plays an important role in cell growth, development, differentiation, apoptosis and various types of injury. For that reason, we have tested the expression of Egr-1 against ER stress inducible drugs (tunicamycin, DTT, A23187 and BFA) to understand what kind of aspect occurred by ER stresses.
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KEYWORD
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TSH (thyroid-stimulating hormone), Egr-1 (early growth response-1 gene), ER (endoplasmic reticulum) stress, UPR (unfolded protein response)
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